Job Description
Sr. Research Associate, Molecular Biology (onsite in Quincy, MA) POSITION SUMMARY The Senior Research Associate will support the Molecular Biology team by contributing to a broad range of laboratory activities, including primer and plasmid design, generation of sequencing preps for hybridoma and single B-cell antibody discovery, PCR, antibody sequencing and analysis, antibody repertoire analysis, and sequence analysis for recombinant protein expression. The position also includes performing antibody engineering workflows such as humanization, mutagenesis, and in silico modeling.
ESSENTIAL FUNCTIONS - Provide molecular biology support for antibody discovery platforms, including hybridoma, Beacon, and cell sorting technologies
- Perform high-throughput PCR-based techniques for gene amplification and sequence analysis, including NGS-based antibody characterization using bioinformatics tools such as Geneious Biologics and Geneious Prime
- Independently design experimental plans, execute complex workflows, and analyze large-scale datasets
- Conduct antibody engineering workflows, including sequence optimization, humanization, and mutagenesis
- Compile, analyze, and present complex datasets to key scientific stakeholders
- Maintain accurate and detailed experimental records in accordance with lab standards
- Manage project timelines effectively and communicate progress, updates, and feedback to Project Management and project leads
- Author technical documentation, including work instructions and standard operating procedures (SOPs)
- Actively contribute to team meetings, routine laboratory responsibilities, and continuous process improvements
POSITION QUALIFICATIONS - B.S. or M.S. in Molecular Biology, Cell Biology, Biotechnology, or a related field
- Minimum 3 years experience and proven proficiency in molecular biology techniques including PCR, DNA purification and quantification, NGS, Sanger sequencing, and sequence analysis
- Proficient in sequence design and analysis using platforms such as Geneious Biologics and Geneious Prime
- Skilled in primer design, recombinant protein expression, and plasmid construction
- Experience in antibody engineering, including humanization, affinity maturation, sequence optimization, and in silico modeling
- Strong understanding of antibody structure and various formats, including antibody fragments, bispecifics, nanobodies, scFvs, and antibody-drug conjugates (ADCs)
- Experience with B-cell isolation and downstream processing for molecular biology applications is a plus
- Familiarity with bioinformatics pipelines and protein modeling software is an advantage
- Able to work independently in a fast-paced, cross-functional, and collaborative environment
- Excellent verbal and written communication skills
- Meticulous attention to detail and strong organizational abilities
- Proven ability to independently troubleshoot and execute complex scientific workflows
- Highly motivated, with a strong work ethic and a commitment to both individual and team success
About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as "writing" DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.
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